Competitive NSAIDS And other CNS Drugs ( Pharmacology ) MCQs – Medical MCQs
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Latest Medical MCQs
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Latest NSAIDS And other CNS Drugs ( Pharmacology ) Mcqs
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Quinine is obtained from CINCHONA________________?
D. Seed capsule
Which of the following drugs can be given safely to a patient with renal disease ?
Thyroid storm can be treated by all the following drugs EXCEPT______________?
Which among the following Not a pharmacological action of opioids______________?
C. Cough suppression
D. Truncal rigidity
Aspirine is useful in all the following conditions EXCEPT_____________?
A. Post myocardial infarction
C. Venous thrombosis
The beneficial effect of drug neostigmine in the treatment of Myasthenia gravis is due to the action____________?
A. It produces more acetycholine receptors
B. It inhibits the action of cholinesterase
C. It is produces more acetylcholine
D. It increases the action of cholinesterase
DOPA and 5-Hydroxytryptophan are clinically important because_____________?
A. They cross blood Brain Barriers
B. They act as neuromodulators
C. They are acidic precursors of Brain amines
D. They are metabolites of various neurogenic amines
Which among the following is a pure antagonist of opioid receptors ?
Which among the following may be used as a sedatives hypnotic ?
An anxiolytic, not interacting with GABA ergic system and used in generalized anxiety is______________?
Folic acid deficiency occurs in______________?
A Hemophiliac patient has rheumatold arthritis. Which drug might be prescribed to relieve the pain ?
C. Acetylsalicylic acid
Activation of which of the following receptors would be expected to decrease anxiety_____________?
A. Nicotinic cholinergic receptors
B. Glucocorticoid receptors
C. GABA receptors
D. Glutamate receptors
Which of the following is a muscle relaxant_________________?
Ibuprofen is contraindicated in_______________?
A. Patient having bronchitis
B. patients having asthma
C. patients having amoebic dysentery
D. patients having fever
The rate of injection of intravenous Valium is_______________?
A. 1 ml / min
B. 1 mg / min
C. 2.5 ml / min
D. 2.5 mg / min
The muscle relaxant effect of succinylcholine lasts for______________?
A. 2 min
B. 1 min
C. 3-5 min
D. 10 min
Aspirin is contraindicated in______________?
B. Person suffering form chicken pox or small pox
C. Peptic ulcer
D. All of the above
Which of the following is a short acting barbiturate ?
Gastric irritation is minimum with one of the following non-steroidal anti inflammatory drugs_____________?
The anti-inflammatory analgesic drug the causes least gastrointestinal symptoms is______________?
A. Phenyl butazone
Paracetamol is contraindicated in_______________?
A. Chronic hepatitis
C. Bleeding disorders
D. A & B
Which of the following drugs is currently widely used in treating opioid dependent individuals?
Birbiturates in pediatrics is_____________?
A. Can be used safely
B. Low safety
D. Not much use
A patient with grand mal epilepsy would likely be under treatment with_____________?
The Ethyl alcohol (Ethanol) is more effective when mixed with water and used as_____________?
A. 20 to 30 percent
B. 10 to 20 percent
C. 40 to 50 percent
D. 60 to 70 percent
Best and most effective drug to control convulsions in toxicity cases is______________?
Which of the following drugs causes extra pyramidal symptoms_____________?
Phenytoin is associated with_____________?
A. Folic acid deficiency
B. Cushing’s syndrome
C. Alzhiemer’s disease
D. Vitamin C deficiency
All of the following statements about opioids is correct except_____________?
A. Ethomorphine is similar to pethidine chemically
B. Pentazocine shows withdrawal symptoms in opioid dependent patients
C. Partial agonists are free from classic opioid adverse effects
D. Pentazocine and buprinorphine
All of the following decrease skeletal muscle tone by CNS effects except____________?
Amitryptyline is a____________?
C. Tricyclic antidepressant
Thiopentone action is terminated by______________?
Phenothiazines are used to____________?
A. Suppress coughing
B. Alter psychotic behaviour
C. Produce muscle relaxation
D. Produce analgesia
Drug that does not cause sedation________________?
Drug which is used to control status epilepticus is______________?
B. Glyceryl trinitrite
C. Sodium nitroprusside
D. Pheno barbital
Prolonged use of aspirin leads to______________?
A. Bleeding defects
B. peptic ulcer
D. A & B
A. Hemolytic anemia
C. Aplastic anemia
Clotting time is most like to be prolonged by the administration of____________?
B. Vitamin K
D. Acetyl salicylic acid
Aspirin is used in treatment of Myocardial Infarction___________?
A. It inhibits thromboxanes
B. It is a vasodilator
C. It stimulates Prostacyclins
D. Ithelps in reducing inflammatory aggregate
Antagonist of morphine is_______________?
Which of the following opioids is not given intrathecally ?
All of the following statements about pain are correct except_____________?
A. Dysphoria is associated with S receptors
B. Analgesia is associated with μ and k receptors
C. NSAIDS benefit by preventing prostaglandin synthesis
D. Naloxane is a non-competitive antagonist and irreversibly opposes the opioids
Aspirin is avoided in children with influenza infection because of association______________?
A. Reye’s syndrome
D. Acid-base imbalance
The most prominent toxic effect associated with acetominophen use is______________?
B. Respiratory alkalosis
C. Hepatic necrosis
D. Gastric Ulceration
An attack of bronchial asthma is most likely to be triggered by________________?
C. Diclofenac potassium
D. Mefenamic acid
E. Both A & B
Narcotic overdose can be antagonized by______________?
Neusea and vomiting that are associated with administration of opioid analgesic is the result of stimulation of the_____________?
A. Emetic system
B. Limbic system
C. Chemoreceptor trigger zone (CTZ)
D. Opioid receptors in G.I.T
Verril’s sign is seen in_________________?
A. Diazepam administration
B. Paget’s disease
C. Digitalis toxicity
D. Unconscious states
A common side effect associated with all NSAID drugs is_______________?
B. Gastric irritation
A paralyzing dose of succinylcholine initially elicits______________?
A. CNS depression
B. Muscle fasciculation
C. CNS stimulation
D. Decreased salivation
Aspirin produces all of the following effects except_____________?
A. Prolonged prothrombin time
B. Frank gastric bleeding
C. Platelet dysfunction
All are true of diazapenes except____________?
A. Clonazeppam is used in the treatment of petitmal epilepsy
B. Benzodiazepam is used in the long term treatment of psychic disorders
C. Benzodiazepam is used in treatment of status epilepticus
D. None of the above
Shortest acting opioid analgesic is______________?
A. Increase BT
B. Increase PTT
C. Increase CT
D. Increase APTT
True about use of midazolam over diazepam is sedation in all except ?
A. Less thrombophlebitis due to low solubility in blond
B. More potent than diazepam
C. More plasma binding and less toxicity
D. Binds to benzodiazepine receptors with 3-4 time more avidly
All NSAIDs block cycloxygenase and____________?
A. Prostaglandin synthesis
B. Preglandin synthesis
C. Ectoglandin synthesis
D. Costaglandin synthesis
Following analgesic combination should be avoided ?
A. Ibuprofen and Paracetamol
B. Paracetamol and Dextropropoxyphene
C. Aspirin and Codeine
D. Ibuprofen and DIclofenac
Which of the following drug induces parkinsonism ?
Which one of the following NSAIDs has adverse effects on liver ?
D. Diclofenac Sodium
Atypical Antipsychotic are all except______________?
Benzodiazepine antagonist is________________?
Which one of the following is NOT an ergot alkaloids_____________?
A. Lysergic acid diethylamide (LSD)
BEnzodiazepines are true in___________________?
A. After metabolism of other drugs in liver
B. More safe than other sedatives when take in larger amounts
C. Produce distortion in sleep more than other sedatives
D. All have metabolically active substrates
Which of the following is true about parasympathetic nervous system ?
A. Ach is transmitter at both pre & post synaptic junction
B. Post ganglionic fibres are longer than pre ganglionic fibres
C. It causes dilatation of skeletal muscles
D. Noradrenalin is the neurotransmitter at post ganglionic junction
Drugs like barbiturates precipitate symptoms of prophyria because______________?
A. They depress ALA synthase
B. They induce heme oxygenase
C. They inhibit ALA synthase
D. They inhibit heme oxygenase
The statement Not true of Selective Cox – 2 inhibitor is________________?
A. The analgesic and anti-inflammatory effects identical to that of Non-selective NSAID
B. Fewer incidence of gastrointestinal side effect
C. Safe in patients with renal insufficiency
D. They do not offer the cardio protective effect
Which one of the following muscle relaxant has the maximum duration of action ?
All are symptoms of opiate withdrawls except______________?
D. Excessive speech
Buprenorphine acts by following mechanism________________?
A. Kappa receptor antagonist
B. Mu receptor antagonist
C. Mu receptor partial agnoist
D. Kappa receptor partial agonist
A patient with grandmal epilepsy would likely be under treatment with_______________?
Respiratory depression is seen with_____________?
C. Synthetic narcotics
The first choice of drug for patitmal seizure is________________?
B. Phentoin sodium
D. None of the above
An untoward effect of that is common to all phenothiazines is______________?
A. Suppression of prolacin
B. Rigidity and tremor at rest, particularly with prolonged use
C. A marked increase in blood pressure
Platelet aggregation in inhibited by all except_______________?
Salicylate administration is contraindicated in pregnancy because_______________?
A. Causes pulmonary hypertension of newborn
B. It delay onset of labour
C. Readily croses placental barrier
D. All of these
Which of the following is a non steroidal anti inflammatory agent with a tendency to produce blood dyscrasias ?
D. B & C
The principle central action of caffeine is on the________________?
A. Cerebral cortex
C. Corpus callosum
D. Spinal cord
An antiepileptic drug used in petitmal epilepsy is______________?
A. Dilantoin sodium
NSAID which undergoes enterohepatic circulation______________?
Acute Barbiturate poisoning results in_______________?
A. Liver failure
B. Renal failure
C. Respiratory failure
One of the obious consequences of alchol ( ethenol), ingestion in many individual is facial flushing and increased heart rate triggered off by alcohol getting metabolized to______________?
A 50 year old female with end stage renal disease (ESRD) develops pulmonary tuberculosis. Which one of the following drugs should be used in a reduced dose ?
Carbamazepine is a type of___________?
Morphine a powerful opioid analgesic drug should be avoided in all the following conditions except____________?
B. Bronchial asthma
C. Left ventricular failure
D. A & C
An attack of migraine can be easily terminated by___________?
One of the benzodiazepines (BDZ) comparatively safe in pregnancy is (Category-B) ?
D. None of the above
Drug which causes gingival hyperplasia_____________?
E. Both A & C
The intramuscular administration of 0.6 mg of atropine sulphate to a 50 kg adult may produce all of the following effects except________________?
B. Decreased sweating
C. Decreased salivation
IV ultrashort acting barbiturate_____________?
Aspirin acts on which part of brain ?
A. Substantia gelatinosa
C. Limbic system
NSAID’s have adverse effect on________________?
Which of the following drug is used to counter act the gastric irritation produced by administration of NSAID_______________?
Prolonged use of aspirin causes_______________?
Salicylate overdose in children causes_______________?
B. Rye’s syndrome
D. None of the above
A patient on 300 mg of aspirin will show all the following except________________?
A. Irreversible inhibition of cyclooxygenase path way
B. Inhibition of thromboxane TXA2
C. Prolonged bleeding time
D. Inhibition of prostaglandin PGI2
Which of the following anti inflammatory drug is a COX-2 inhibitor_____________?
Pregnant patient can be safely given______________?
Aspirin is contraindicated in_______________?
C. Peptic ulcer
Less gastrointestinal bleed is seen in the following NSAID_______________?
C. C0X2 specific inhibitors
Which of the following anti-epileptic agents causes the reversible side-effect of gingival hyperplasia ?
C. Sodium valporate
D. None of the above
Amyl nitrate is most commonly administered _________________?
A. By inhalation
C. Sub lingually
Which of the following is a nonsteroldad anti inflammatory agent with a tendency to produce blood dyscriasis ?
A. Indomathecin (indocin)
C. Ibuprofen (Motrin)
Which of the following is an irreversible side enact resulting from long term administration of phenothiazline antipsychotics__________________?
B. Tardive dyskinesia
D. B & C
Which of the following can be given safely to a patient of congestive heart failure________________?
A. Diclofenac sodium
Which of the following is not a contraindication in the therapy with opioids_____________?
A. use in impaired pulmonary function
B. Use in head injury patient
C. Use of agonist with mixed agonist-antagonist
D. Use in severe constant pain
Morphine is contraindicated in all of the following except_______________?
A. Pulmonary oedema
B. Bronchial asthma
D. Head injury
Which of the following drugs is least efficacious in the treatment of cemporal lobe epilepsy ?
A. Phenytoin sodium